Antibody Engineering: Shaping the Future of Therapeutics

  Antibody engineering transforms natural immune proteins into highly effective therapeutics by improving their stability, specificity, and immune functions. Techniques like CDR grafting allow humanizing antibodies to reduce immunogenicity, while phage and yeast display libraries enable rapid selection of high-affinity candidates. Site-specific conjugation further enhances therapies by precisely linking antibodies to drugs, creating potent antibody-drug conjugates with targeted delivery. Engineering also addresses challenges such as scalable production and safety, paving the way for innovative multi-functional antibodies that can engage multiple immune pathways simultaneously, offering promising solutions for complex diseases like cancer and autoimmune disorders.