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金欢欢
发布人:陶灿 发布时间:2021-11-17  浏览次数:10

教师简介:金欢欢,汉族,博士研究生,讲师,硕士生导师(中医药防治慢性肝病及肿瘤作用及机制研究)。在中国药理学会2020年首届药理学青年教师网络授课展示活动”中荣获三等奖,参编中国科学技术大学出版社出版的《药理学》第三版、《护理药理学》第三版。

【主要研究方向】中医药防治慢性肝病及肿瘤作用及机制研究

【联系方式】jhhwnmc@163.com;18351895392

【教育学习经历】

201509——201806月  南京中医药大学中药学专业  博士

201309——201506月  南京中医药大学药理学专业  硕士

200909——201306月  安徽新华学院药学专业  本科

【主要科研项目】

1. 国家自然科学基金青年项目,莪术醇调控CCF抗酒精性脂肪肝中肝细胞衰老的作用机制, 项目批准号:81900531, 主持,在研

2. 2019年度安徽高校自然科学研究项目重点项目,LncRNA MARA/YAP调控病理性铁超载抗非酒精性脂肪肝中肝细胞衰老的作用机制, 项目批准号:KJ2019A0428, 费用:6.00万元,主持,结题

【近五年代表性论文】

1. Xiaoyu Qi, Anping Song, Mingyue Ma, Peipei Wang, Xinbei Zhang, Chunfeng Lu, Junxiu Zhang, Shuguo Zheng*, Huanhuan Jin*. Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease[J]. Cell Proliferation. 2021; 54: e13107.

2. Ping Yuan, Xiaoyu Qi, Anping Song, Mingyue Ma, Xinbei Zhang, Chunfeng Lu, Mianli Bian, Naqi Lian, Jianling He, Shuguo Zheng*, Huanhuan Jin*. LncRNA MAYA promotes iron overload and hepatocyte senescence through inhibition of YAP in non-alcoholic fatty liver disease[J]. J Cell Mol Med. 2021; 25: 7354–7366.

3. 金欢欢. 药理学专业研究生培养之思考[J]科教文汇. 2021; (9): 132-133.

4. Yiming Jiang, Ying Zhou, Wenxuan Xu, Xinqi, Wang, Huanhuan Jin, Xiaofeng Bao, Chunfeng Lu. Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy[J]. Cell Biol Toxicol.2021. ( doi.org/10.1007/s10565-021-09635-8)

5. Jia Y, Jin H, Gao L, Yang X, Wang F, Ding H, Chen A, Tan S, Zhang F, Shao J, Wang S, Zheng S*. A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP mediated cell senescence. J Cell Mol Med. 2020; 24: 5304–5316. Jia, Jin and Gao contributed equally to this work.

6. Bian M, He J, Jin H, Lian N, Shao J, Guo Q, Wang S, Zhang F. Zheng S*.Oroxylin A induces apoptosis of activated hepatic stellate cells through endoplasmic reticulum stress, Apoptosis.2019;24(11-12):905-920.

7. Jin H, Lian N, Bian M, Zhang C, Chen X, Shao J, Wu L, Chen A, Guo Q, Zhang F, Zheng S*. Oroxylin A inhibits ethanol-induced hepatocyte senescence via YAP pathway, Cell proliferation. 2018; 51(3): e12431.

8. Jin H, Lian N, Bian M, Zhang C, Chen X, Shao J, Wu L, Chen A, Guo Q, Zhang F, Zheng S*. Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha. Chem-Biol Interact. 2018; 285: 14-20.

9. Zhang C, Bian M, Chen X, Jin H, Zhao S, Yang X, Shao J, Chen A, Guo Q, Zhang F, Zheng S*. Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1alpha signaling. J Cell Biochem. 2018; 119(2):2258-2268.

10. Jia Y, Wang F, Guo Q, Li M, Wang L, Zhang Z, Jiang S. Jin H. Chen A. Tan S. Zhang F. Shao J. Zheng S. Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells. Redox Biol, 2018; 19: 375-387.

11. Jin H, Jia Y, Yao Z, Huang J, Hao M, Yao S, Lian N, Zhang F, Zhang C, Chen X, Bian M, Shao J, Wu L, Chen A, Zheng S*. Hepatic stellate cell interferes with NK cell regulation of fibrogenesis via curcumin induced senescence of hepatic stellate cell. Cell Signal. 2017; 33: 79-85.

12. Zhang F, Hao M, Jin H, Yao Z, Lian N, Wu L, Shao J, Chen A, Zheng S*. Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis. Br J Pharmacol. 2017; 174(5): 409-423.

13. Bian M, Chen X, Zhang C, Jin H, Wang F, Shao J, Chen A, Zhang F, Zheng S*. Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesis in vitro and in vivo. Bio factors. 2017; 43(6): 836-846.

14. Chen X, Bian M, Zhang C, Kai J, Yao Z, Jin H, Lu C, Shao J, Chen A, Zhang F, Zheng S*. Dihydroartemisinin inhibits ER stress-mediated mitochondrial pathway to attenuate hepatocyte lipoapoptosis via blocking the activation of the PI3K/Akt pathway. Biomed Pharmacother. 2017; 97: 975-984.


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